期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41598-021-93045-7
关键词
-
资金
- Ministry of Education, Science, Sports and Culture of Japan [18K03178]
- Japan Science and Technology Agency
- Career Assistant Project in Hiroshima University
- Novartis Pharma K.K., Japan
- Ono Pharmaceutical Co, Ltd.
- Grants-in-Aid for Scientific Research [18K03178] Funding Source: KAKEN
The study uncovered the distinct roles of cholinergic neurons in different brain regions in social interaction and social recognition memory through selective elimination in mice. Treatment with cholinesterase inhibitors restored social ability deficits associated with Alzheimer's disease symptoms, highlighting the crucial role of the cholinergic system in social behavior.
Social behaviour is a complex construct that is reported to include several components of social approach, interaction and recognition memory. Alzheimer's disease (AD) is mainly characterized by progressive dementia and is accompanied by cognitive impairments, including a decline in social ability. The cholinergic system is a potential constituent for the neural mechanisms underlying social behaviour, and impaired social ability in AD may have a cholinergic basis. However, the involvement of cholinergic function in social behaviour has not yet been fully understood. Here, we performed a selective elimination of cholinergic cell groups in the basal forebrain in mice to examine the role of cholinergic function in social interaction and social recognition memory by using the three-chamber test. Elimination of cholinergic neurons in the medial septum (MS) and vertical diagonal band of Broca (vDB) caused impairment in social interaction, whereas ablating cholinergic neurons in the nucleus basalis magnocellularis (NBM) impaired social recognition memory. These impairments were restored by treatment with cholinesterase inhibitors, leading to cholinergic system activation. Our findings indicate distinct roles of MS/vDB and NBM cholinergic neurons in social interaction and social recognition memory, suggesting that cholinergic dysfunction may explain social ability deficits associated with AD symptoms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据