Common neurobiological correlates of resilience and personality traits within the triple resting-state brain networks assessed by 7-Tesla ultra-high field MRI

Despite numerous studies investigating resilience and personality trials, a paucity of information regarding their neurobiological commonalities at the level of the large resting-state networks (rsNWs) remains. Here we address this topic using the advantages of ultra-high-field (UHF) 7T-MRI, characterized by higher signal-to-noise ratio and increased sensitivity. The association between resilience, personality traits and three fMRI measures (fractional amplitude of low-frequency fluctuations (fALFF), degree centrality (DC) and regional homogeneity (ReHo)) determined for three core rsNWs (default mode (DMN), salience (SN), and central executive network (CEN)) were examined in 32 healthy volunteers. The investigation revealed a significant role of SN in both resilience and personality traits and a tight association of the DMN with resilience. DC in CEN emerged as a significant moderator for the correlations of resilience with the personality traits of neuroticism and extraversion. Our results indicate that the common neurobiological basis of resilience and the Big Five personality traits may be reflected at the level of the core rsNWs.

Automated summary

Despite previous studies, there is still a lack of information on the common neurobiological basis of resilience and personality traits at the level of the large resting-state networks. Using ultra-high-field 7T-MRI, this study found that the salience network (SN) plays a significant role in both resilience and personality traits, while the default mode network (DMN) is closely associated with resilience. Additionally, the degree centrality (DC) in the central executive network (CEN) emerged as a significant moderator for the correlations between resilience and neuroticism and extraversion traits.