期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-92384-9
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资金
- United States-Israel Binational Science Foundation (BSF) [2015034]
There are significant differences in the prenatal and postnatal development of mucosal enteric glial cells (mEGC) between mice and humans, with mEGCs absent at birth in mice but already present in human fetal gut. Additionally, xenograft experiments show that human mEGCs are more persistent in immuno-compromised mouse hosts compared to murine mEGCs. Single cell RNAseq also indicates disparities in developmental dynamics and gene expression patterns between human and mouse mEGCs.
In mammals, neural crest cells populate the gut and form the enteric nervous system (ENS) early in embryogenesis. Although the basic ENS structure is highly conserved across species, we show important differences between mice and humans relating to the prenatal and postnatal development of mucosal enteric glial cells (mEGC), which are essential ENS components. We confirm previous work showing that in the mouse mEGCs are absent at birth, and that their appearance and homeostasis depends on postnatal colonization by microbiota. In humans, by contrast, a network of glial cells is already present in the fetal gut. Moreover, in xenografts of human fetal gut maintained for months in immuno-compromised mice, mEGCs persist following treatment with antibiotics that lead to the disappearance of mEGCs from the gut of the murine host. Single cell RNAseq indicates that human and mouse mEGCs differ not only in their developmental dynamics, but also in their patterns of gene expression.
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