期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-96341-4
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资金
- Marsden Fund [UOO1701]
Research shows that the excitability of CRH neurons is regulated over the estrous cycle, with peak excitability in proestrus and lowest in estrus. Additionally, the relationship between I-A currents and excitability is opposite, and blocking I-A currents can equalize excitability across cycle stages, indicating a role for I-A in mediating plasticity in stress circuit function over the female estrous cycle.
Stress responses are highly plastic and vary across physiological states. The female estrous cycle is associated with a number of physiological changes including changes in stress responses, however, the mechanisms driving these changes are poorly understood. Corticotropin-releasing hormone (CRH) neurons are the primary neural population controlling the hypothalamic-pituitary-adrenal (HPA) axis and stress-evoked corticosterone secretion. Here we show that CRH neuron intrinsic excitability is regulated over the estrous cycle with a peak in proestrus and a nadir in estrus. Fast inactivating voltage-gated potassium channel (I-A) currents showed the opposite relationship, with current density being lowest in proestrus compared to other cycle stages. Blocking I-A currents equalized excitability across cycle stages revealing a role for I-A in mediating plasticity in stress circuit function over the female estrous cycle.
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