Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour

Zhoushan cattle are an endangered cattle breed in the Zhoushan islands in China. Since Zhoushan cattle have been bred in isolation, they show unique characteristics, such as dark black coat colour. However, no studies have been conducted on the genome of Zhoushan cattle. Here, we performed whole-genome sequencing of seven individuals of Zhoushan cattle and nine cattle in Wenling, geographically close to the Zhoushan islands. By integrating our data and publicly-available data, we found that Zhoushan cattle are genetically highly similar to Bos indicus cattle in south-eastern China. Furthermore, by identifying the genomic regions shared between Zhoushan cattle and Angus cattle, a Bos taurus breed, we found that the p.F195L mutation in melanocyte-stimulating hormone receptor (MC1R) could be associated with their dark black coat colour. Taken together, our results provide a valuable resource for characterising the uniqueness of Zhoushan cattle.

Automated summary

Zhoushan cattle, an endangered breed from Zhoushan islands in China, show unique characteristics and are genetically similar to Bos indicus cattle in southeastern China. The dark black coat color of Zhoushan cattle may be associated with a specific mutation in the MC1R gene, as revealed by shared genomic regions with Angus cattle. Our study provides valuable insights into the uniqueness of Zhoushan cattle.