4.7 Article

Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice

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Gut microbiome partially mediates and coordinates the effects of genetics on anxiety-like behavior in Collaborative Cross mice

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Summary: This study used a mouse model to investigate the relationship between anxiety behavior, host genetic factors, and gut microbiome composition. Through GWAS and microbiome composition analysis, genes related to anxiety and depression were identified, along with differences in microbiome composition between high and low anxiety mice. The findings suggest that the gut microbiome partially mediates and coordinates the effects of genetics on anxiety.

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