期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 235, 期 -, 页码 70-77出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2016.06.008
关键词
Mycoplasma gallisepticum; House finch; Corticosterone; Sickness behavior; Acute phase response; Inflammation
资金
- National Science Foundation Research Experiences for Undergraduates supplement [EF-0622705]
- NSF [IOS-1054675, IOS-1145625]
- Virginia Tech's Organismal Biology and Ecology (OBE) Interdisciplinary Grant
- Virginia Tech's Department of Biological Sciences Stacey Smith Biology Research Excellence Fund
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1145625, 1054675] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [GRANTS:14035669] Funding Source: National Science Foundation
Glucocorticoid stress hormones are important for energy mobilization as well as regulation of the immune system, and thus these hormones are particularly likely to both influence and respond to pathogen infection in vertebrates. In this study, we examined how the glucocorticoid stress response in house finches (Haemorhous mexicanus) interacts with experimental infection of the naturally-occurring bacterial pathogen, Mycoplasma gallisepticum (MG). We also investigated whether infection-induced concentrations of corticosterone (CORT), the primary glucocorticoid in birds, were associated with the expression of sickness behavior, the lethargy typically observed in vertebrates early in infection. We found that experimental infection with MG resulted in significantly higher CORT levels on day 5 post infection, but this effect appeared to be limited to female house finches only. Regardless of sex, infected individuals with greater disease severity had the highest CORT concentrations on day 5 post-infection. House finches exposed to MG exhibited behavioral changes, with infected birds having significantly lower activity levels than sham-inoculated individuals. However, CORT concentrations and the extent of sickness behaviors exhibited among infected birds were not associated. Finally, pre-infection CORT concentrations were associated with reduced inflammation and pathogen load in inoculated males, but not females. Our results suggest that the house finch glucocorticoid stress response may both influence and respond to MG infection in sex-specific ways, but because we had a relatively low sample size of males, future work should confirm these patterns. Finally, manipulative experiments should be performed to test whether the glucocorticoid stress response acts as a brake on the inflammatory response associated with MG infection in house finches. (C) 2016 Elsevier Inc. All rights reserved.
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