4.7 Article

Knockout of CaV1.3 L-type calcium channels in a mouse model of retinitis pigmentosa

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Summary: The Ca(V)1.4 L-type calcium channels play a crucial role in synaptic transmission in photoreceptor terminals. Mutations in the encoding gene are associated with congenital stationary night blindness type-2, affecting scotopic and photopic vision. The Ca(V)1.4-IT mutation in mice leads to impairments in cone pathways and synaptic transmission deficits that cannot be rescued by calcium channel blockers.

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