The association between fluoroquinolones and aortic dissection and aortic aneurysms: a systematic review and meta-analysis

Previous studies have drawn causal associations between fluoroquinolone use and collagen pathologies including tendon rupture and retinopathy. This meta-analysisattempted to assess the association between fluoroquinolone use and the risk of aortic dissection or aortic aneurysm. A systematic search was performed on Medline, EMBASE, and the Cochrane library. 9 studies were included in final analysis. Primary random-effects meta-analysis of 7 studies, excluding 2 pharmacovigilance studies demonstrated statistically increased odds of aortic dissection (OR, 2.38; 95% CI, 1.71-3.32) aortic aneurysm (OR, 1.98; 95% CI, 1.59-2.48), and aortic aneurysm or dissection (OR, 1.47; 95% CI, 1.13-1.89; I-2=72%) with current use of fluoroquinolones compared to their nonuser counterparts. Based on the number needed-to-harm analysis, 7246 (95% CI: 4329 to 14,085) patients would need to be treated with fluoroquinolones for a duration of at least three days in order for one additional patient to be harmed, assuming a population baseline incidence of aortic dissection and aneurysm rupture to be 10 per 100,000 patient-years. With strong statistical association, these findings suggest a causal relationship, warranting future research to elucidate the pathophysiological and mechanistic plausibility of this association. These findings however, should not cease prescription of fluoroquinolones, especially when clinically indicated.

Automated summary

Previous studies have shown a causal association between fluoroquinolone use and collagen pathologies, while this meta-analysis found a statistically significant risk of aortic dissection or aneurysm associated with current fluoroquinolone use. Further research is needed to understand the mechanistic plausibility of this association, but caution should be exercised in prescribing fluoroquinolones, especially when clinically necessary.