期刊
NUTRIENTS
卷 13, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/nu13061843
关键词
breast cancer; folate; choline; betaine; methionine; EPIC
资金
- Research Foundation Flanders (FWO) [189019N, V427019N]
- International Agency for Research on Cancer (IARC)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Danish Cancer Society (Denmark)
- Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
- German Cancer Aid (Germany)
- German Cancer Research Center (DKFZ) (Germany)
- German Institute of Human Nutrition Potsdam Rehbruecke (DIfE) (Germany)
- Federal Ministry of Education and Research (BMBF) (Germany)
- Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy (Italy)
- Compagnia di SanPaolo and National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports (VWS) (The Netherlands)
- Netherlands Cancer Registry (NKR) (The Netherlands)
- LK Research Funds (The Netherlands)
- Dutch Prevention Funds (The Netherlands)
- Dutch ZON (Zorg Onderzoek Nederland) (The Netherlands)
- World Cancer Research Fund (WCRF) (The Netherlands)
- Statistics Netherlands (The Netherlands) (Spain)
- Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII) (Spain)
- Regional Government of Andalucia (Spain)
- Regional Governments of Asturias (Spain)
- Regional Governments of Basque Country (Spain)
- Regional Governments of Murcia (Spain)
- Regional Governments of Navarra (Spain)
- Swedish Cancer Society (Sweden)
- Swedish Research Council (Sweden)
- County Council of Skane (Sweden)
- County Council of Vasterbotten (Sweden)
- Cancer Research UK, (United Kingdom) [14136, C8221/A29017]
- Medical Research Council, (United Kingdom) [1000143, MR/M012190/1]
- MRC [MR/M012190/1] Funding Source: UKRI
The study did not find strong evidence for an association between methyl-group donors involved in one-carbon metabolism and breast cancer risk. However, there was a potential U-shaped trend suggested for dietary folate intake and breast cancer risk. Further research is needed to clarify this association.
(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992-2000 and December 2013-December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 mu g/day compared to a reference intake of 205 mu g/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.
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