期刊
NUTRIENTS
卷 13, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nu13092989
关键词
Bacteroides uniformis; high-fat diet; non-alcoholic fatty liver disease; hepatic steatosis; lipid metabolism
资金
- Main Research Program of the Korea Food Research Institute (KFRI) - Ministry of Science and ICT [E0210602-01, E0170601-04]
- KFRI [E0210602-01]
Bacteroides uniformis CBA7346 ameliorates high-fat diet-induced non-alcoholic fatty liver disease by reducing insulin resistance and regulating de novo lipogenesis.
Dietary habits and gut microbiota play an essential role in non-alcoholic fatty liver disease (NAFLD) and related factors such as insulin resistance and de novo lipogenesis. In this study, we investigated the protective effects of Bacteroides uniformis CBA7346, isolated from the gut of healthy Koreans, on mice with high-fat diet (HFD)-induced NAFLD. Administration of B. uniformis CBA7346 reduced body and liver weight gain, serum alanine aminotransferase and aspartate aminotransferase levels, liver steatosis, and liver triglyceride levels in mice on an HFD; the strain also decreased homeostatic model assessment for insulin resistance values, as well as serum cholesterol, triglyceride, lipopolysaccharide, leptin, and adiponectin levels in mice on an HFD. Moreover, B. uniformis CBA7346 controlled fatty liver disease by attenuating steatosis and inflammation and regulating de novo lipogenesis-related proteins in mice on an HFD. Taken together, these findings suggest that B. uniformis CBA7346 ameliorates HFD-induced NAFLD by reducing insulin resistance and regulating de novo lipogenesis in obese mice.
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