期刊
NUTRIENTS
卷 13, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nu13072390
关键词
bioactive compounds; nutraceutical; maternal obesity; adipose tissue; metabolic disorders
资金
- Brazilian National Council for Scientific and Technological Development (CNPq) [305402/2019-6]
- Coordination for the Improvement of Higher Education Personnel (CAPES, Ministry of Education of Brazil)
- Instituto de Salud Carlos III [CD19/00228]
This review summarizes the effects of dietary polyphenols on obesity-induced maternal reprogramming as an offspring anti-obesity approach.
Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotype and predispose offspring to metabolic disorders such as obesity. This increased risk may also be epigenetically transmitted across generations. Thus, there is an imperative need to find effective reprogramming approaches in order to resume normal fetal development. Polyphenols are bioactive compounds found in vegetables and fruits that exert its anti-obesity effect through its powerful anti-oxidant and anti-inflammatory activities. Polyphenol supplementation has been proven to counteract the prejudicial effects of maternal obesity programming on progeny. Indeed, some polyphenols can cross the placenta and protect the fetal predisposition against obesity. The present review summarizes the effects of dietary polyphenols on obesity-induced maternal reprogramming as an offspring anti-obesity approach.
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