期刊
NUTRIENTS
卷 13, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/nu13082890
关键词
Allium hookeri; dementia; memory; neuroprotective; scopolamine
资金
- Rural Development Administration, Republic of Korea [PJ01586301, PJ01327901]
Allium hookeri (AH) is a medicinal food used in Southeast Asia with positive effects in relieving memory impairment induced by scopolamine, especially the root extracts. AH improves cognitive effects by enhancing the cholinergic system, inhibiting neuroinflammation, and providing neuroprotective effects.
Allium hookeri (AH) is a medicinal food that has been used in Southeast Asia for various physiological activities. The objective of this study was to investigate the activation of the cholinergic system and the anti-neuroinflammation effects of AH on scopolamine-induced memory impairment in mice. Scopolamine (1 mg/kg body weight, i.p.) impaired the performance of the mice on the Y-maze test, passive avoidance test, and water maze test. However, the number of error actions was reduced in the AH groups supplemented with leaf and root extracts from AH. AH treatment improved working memory and avoidance times against electronic shock, increased step-through latency, and reduced the time to reach the escape zone in the water maze test. AH significantly improved the cholinergic system by decreasing acetylcholinesterase activity, and increasing acetylcholine concentration. The serum inflammatory cytokines (IL-1 beta, IL-6, and IFN-gamma) increased by scopolamine treatment were regulated by the administration of AH extracts. Overexpression of NF-kappa B signaling and cytokines in liver tissue due to scopolamine were controlled by administration of AH extracts. AH also significantly decreased A beta and caspase-3 expression but increased NeuN and ChAT. The results suggest that AH extracts improve cognitive effects, and the root extracts are more effective in relieving the scopolamine-induced memory impairment. They have neuroprotective effects and reduce the development of neuroinflammation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据