4.7 Article

Evaluation of the Cholesterol-Lowering Mechanism of Enterococcus faecium Strain 132 and Lactobacillus paracasei Strain 201 in Hypercholesterolemia Rats

期刊

NUTRIENTS
卷 13, 期 6, 页码 -

出版社

MDPI
DOI: 10.3390/nu13061982

关键词

cholesterol-lowering; Enterococcus faecium strain 132; Lactobacillus paracasei strain 201; gut microbiota

资金

  1. Key-Area Research and Development Program of Guangdong Province [2018B020205002]
  2. Department of Science and Technology of Guangdong Province [2019QN01N107]
  3. GDAS' Project of Science and Technology Development for Capacity Building of Innovation Driven Development [2019GDASYL-0201001]

向作者/读者索取更多资源

The study found that Enterococcus faecium strain 132 and Lactobacillus paracasei strain 201 can effectively lower blood lipids, improve cholesterol metabolism, and reduce fat accumulation. Additionally, these two strains can alleviate symptoms of hypercholesterolemia by regulating gut microbiota and increasing levels of acetic acid and propionic acid in the intestines.
Hypercholesterolemia can cause many diseases, but it can effectively regulated by Lactobacillus. This study aimed to evaluate the cholesterol-lowering mechanism of Enterococcus faecium strain 132 and Lactobacillus paracasei strain 201. These results showed that both the strains decreased serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), liver TC and TG and increased fecal TC, TG and total bile acid (TBA) levels. Additionally, both strains also reduced glutamic-pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST) and levels of tissue inflammation levels to improve the lipid profile, and they reduced fat accumulation partially by alleviating inflammatory responses. Furthermore, both strains regulated the expression of the CYP8B1, CYP7A1, SREBP-1, SCD1 and LDL-R gene to promote cholesterol metabolism and reduce TG accumulation. Interventions with both strains also altered the gut microbiota, and decreasing the abundance of Veillonellaceae, Erysipelotrichaceae and Prevotella. Furthermore, fecal acetic acid and propionic acid were increased by this intervention. Overall, the results suggested that E. faecium strain 132 and L. paracasei strain 201 can alleviate hypercholesterolemia in rats and might be applied as a new type of hypercholesterolemia agent in functional foods.

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