期刊
NUTRIENTS
卷 13, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/nu13082771
关键词
black garlic; methanol extract; LC-ESI; LTQOrbitrap; MS; MS; secondary metabolites; cellular bioactivity; cancer cells
资金
- EU BLUEPRINT [282510]
- Italian Flagship Project EPIGEN, Programma di Ricerca Scientifica di Rilevante Interesse Nazionale PRIN-2015 [20152TE5PK_003]
- Italian Association for Cancer Research [AIRC-17217]
- Programma VALERE (Vanvitelli per la Ricerca)
Garlic has been traditionally used as a food ingredient and remedy for diseases, with black garlic gaining popularity recently. A study found that major components in black garlic extract include sulfur derivatives, saccharides, peptides, and organic acids, showing antioxidant, metabolic, and hepatoprotective effects in cancer cells, as well as inducing maturation of acute myeloid leukemia cells. These findings suggest that black garlic consumption could potentially prevent metabolic and tumor diseases.
Over the centuries, humans have traditionally used garlic (Allium sativum L.) as a food ingredient (spice) and remedy for many diseases. To confirm this, many extensive studies recognized the therapeutic effects of garlic bulbs. More recently, black garlic (BG), made by heat-ageing white garlic bulbs, has increased its popularity in cuisine and traditional medicine around the world, but there is still limited information on its composition and potential beneficial effects. In this study, the metabolite profile of methanol extract of BG (BGE) was determined by high-performance liquid chromatography coupled to tandem mass spectrometry in high-resolution mode. Results allowed to establish that BGE major components were sulfur derivatives, saccharides, peptides, organic acids, a phenylpropanoid derivative, saponins, and compounds typical of glycerophospholipid metabolism. Characterization of the BGE action in cancer cells revealed that antioxidant, metabolic, and hepatoprotective effects occur upon treatment as well as induction of maturation of acute myeloid leukemia cells. These results are interesting from the impact point of view of BG consumption as a functional food for potential prevention of metabolic and tumor diseases.
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