4.7 Review

Primary Prevention of Food Allergy-Environmental Protection beyond Diet

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Summary: The study found that characteristics of the infant gut microbiota at 3 months were related to cesarean birth, with a higher abundance of Clostridium sensu stricto at 3 months being positively correlated with atopic dermatitis. Transition to Bacteroides-rich communities and influx of adult-specific microbes were observed during the first year of life in selected cases and controls with longitudinal samples. The introduction of allergenic solids from 3 months alongside breast-feeding led to a significant increase in Shannon diversity and specific microbial representation, such as genera belonging to Prevotellaceae and Proteobacteria (e.g. Escherichia/Shigella).

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EAACI guideline: Preventing the development of food allergy in infants and young children (2020 update)

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Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

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