期刊
NUTRIENTS
卷 13, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/nu13062029
关键词
gut microbiota; sugar alcohol; diarrhea
资金
- JSPS KAKENHI [JP17H05068, JP20K21530, JP20H03490]
- AMED [JP18gm6010004h0003]
- Takeda Science Foundation
- Naito Foundation
- Yakult Bio-Science Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
Specific gut bacteria, such as Escherichia coli from the Enterobacteriaceae family, play a key role in suppressing sorbitol-induced diarrhea by degrading sorbitol in the intestine. The findings suggest that the gut microbiota's ability to respond to and break down sugar alcohols has implications for microbiome science, processed food science, and public health.
While poorly-absorbed sugar alcohols such as sorbitol are widely used as sweeteners, they may induce diarrhea in some individuals. However, the factors which determine an individual's susceptibility to sugar alcohol-induced diarrhea remain unknown. Here, we show that specific gut bacteria are involved in the suppression of sorbitol-induced diarrhea. Based on 16S rDNA analysis, the abundance of Enterobacteriaceae bacteria increased in response to sorbitol consumption. We found that Escherichia coli of the family Enterobacteriaceae degraded sorbitol and suppressed sorbitol-induced diarrhea. Finally, we showed that the metabolism of sorbitol by the E. coli sugar phosphotransferase system helped suppress sorbitol-induced diarrhea. Therefore, gut microbiota prevented sugar alcohol-induced diarrhea by degrading sorbitol in the gut. The identification of the gut bacteria which respond to and degrade sugar alcohols in the intestine has implications for microbiome science, processed food science, and public health.
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