期刊
NUTRIENTS
卷 13, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nu13093257
关键词
fetal undernutrition; myo-inositol; leptin; lactation period; metabolic programming; arcuate nucleus; paraventricular nucleus; PBMC
资金
- Spanish Government (MCIU/AEI/FEDER, UE) [PGC2018-097436-B-I00]
- Instituto de Salud Carlos III, Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion, CIBERobn
- Spanish Government
It was found in this study that myo-inositol supplementation during lactation can reverse the effects of fetal malnutrition on hypothalamic structure and metabolic health biomarkers in PBMC in rats, partially due to increased leptin sensitivity.
We studied whether myo-inositol supplementation throughout lactation, alone and combined with leptin, may reverse detrimental effects on hypothalamic structure and function caused by gestational calorie gestation (CR) in rats. Candidate early transcript-based biomarkers of metabolic health in peripheral blood mononuclear cells (PBMC) were also studied. Offspring of dams exposed to 25% gestational CR and supplemented during lactation with physiological doses of leptin (CR-L), myo-inositol (CR-M), the combination (CR-LM), or the vehicle (CR-V) as well as control rats (CON-V) were followed and sacrificed at postnatal day 25. Myo-inositol and the combination increased the number of neurons in arcuate nucleus (ARC) (only in females) and paraventricular nucleus, and myo-inositol (alone) restored the number of alpha MSH+ neurons in ARC. Hypothalamic mRNA levels of Lepr in CR-M and Insr in CR-M and CR-LM males were higher than in CR-V and CON-V, respectively. In PBMC, increased expression levels of Lrp11 and Gls in CR-V were partially normalized in all supplemented groups (but only in males for Gls). Therefore, myo-inositol supplementation throughout lactation, alone and combined with leptin, reverts programmed alterations by fetal undernutrition on hypothalamic structure and gene expression of potential early biomarkers of metabolic health in PBMC, which might be attributed, in part, to increased leptin sensitivity.
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