期刊
NUTRIENTS
卷 13, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nu13093155
关键词
catechins; diabetes; diet; gut microbiome; tea
资金
- John Colaizzi Endowment Chair Fund
Green tea extracts and tea catechins are effective in preventing or alleviating diabetes, with powder form green tea leaves (GTP) potentially less effective than green tea extracts (GTE). The study found that 1% GTE was beneficial in preventing diabetes development, while 1% GTP may lead to increased food intake and elevated blood glucose. Furthermore, adjustments in gut microbiota were also associated with the progression of diabetes.
Green tea extracts and tea catechins have been shown to prevent or alleviate diabetes. The present study tests the hypothesis that green tea leaves in powder form (GTP), which also contain fiber and other water non-extractable materials, are more effective than the corresponding green tea extracts (GTE) in impeding the development of diabetes in db/db mice. Female db/db mice were treated with a diet containing 1% of GTE, 2% of GTE, 2% of GTP (with the same catechin content as 1% GTE) or 1% GTP. The 1% GTE group had lower food intake, water consumption, body weight and fasting blood glucose levels than the control group, while 2% GTP did not have any significant effect. Dietary 1% GTE also preserved beta-cell insulin secretion. However, 1% GTP increased food intake, water consumption and blood glucose levels. Microbiome analysis with 16S rRNA gene V4 sequencing showed that the gut microbiota was modified by GTE and GTP, and a few bacterial guilds were associated with blood glucose levels. In the Random Forest regression model, the leading predictor of metabolic outcome was food consumption, followed by changes in some bacterial guilds. The results illustrate the importance of food consumption and gut microbiota in affecting the progression of diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据