期刊
MATERIALS
卷 14, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/ma14133443
关键词
supported ionic liquid phase; biocatalysis; lipase; chemo-enzymatic Baeyer-Villiger oxidation; heterogeneous catalysis; carbon nanotubes; immobilization
类别
资金
- Silesian University of Technology (Poland) [04/050/RGJ21/0122]
- National Science Centre (Poland) [2019/33/N/ST8/00479]
- National Agency for Academic Exchange of Poland [PPI/APM/2018/1/00004]
A novel method was developed for chemo-enzymatic Baeyer-Villiger oxidation of cyclic ketones using supported ionic liquid-like phase biocatalyst. Lipases from different sources were immobilized on multi-walled carbon nanotubes anchored to ionic liquids covalently. The biocatalysts showed high activity and stability in the oxidation of 2-adamantanone, achieving high conversion rates under favorable reaction conditions.
A novel method for chemo-enzymatic Baeyer-Villiger oxidation of cyclic ketones in the presence of supported ionic liquid-like phase biocatalyst was designed. In this work, multi-walled carbon nanotubes were applied as a support for ionic liquids which were anchored to nanotubes covalently by amide or imine bonds. Next, lipases B from Candida antarctica, Candida rugosa, or Aspergillus oryzae were immobilized on the prepared materials. The biocatalysts were characterized using various techniques, like thermogravimetry, IR spectroscopy, XPS, elemental analysis, and SEM-EDS microscopy. In the proposed approach, a biocatalyst consisting of a lipase as an active phase allowed the generation of peracid in situ from the corresponding precursor and a green oxidant-hydrogen peroxide. The activity and stability of the obtained biocatalysts in the model oxidation of 2-adamantanone were demonstrated. High conversion of substrate (92%) was achieved under favorable conditions (toluene: n-octanoic acid ratio 1:1 = v:v, 35% aq. H2O2 2 eq., 0.080 g of biocatalyst per 1 mmol of ketone at 20 degrees C, reaction time 4 h) with four reaction cycles without a drop in its activity. Our 'properties-by-design' approach is distinguished by its short reaction time at low temperature and higher thermal stability in comparison with other biocatalysts presented in the literature reports.
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