期刊
GENE
卷 590, 期 2, 页码 193-200出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2016.03.048
关键词
ARE; AP-1 repressor; Function; Histone chaperone; JDP2; ROS; Structure
资金
- National Institutes of Health [GM089820]
- Elsevier
- Ministry of Science and Technology [MOST-104-2320-B-037-033-My2, MOST-104-2314-B-037-002, MOST104-2811-B-037-015]
- National Health Research Institutes [NHRI-Ex104-10416SI]
- Kaohsiung Medical University [KMU-TP103A04, KMU-TP103G03, KMU-TP104E23, KMU-DT104001]
The Jun dimerization protein 2 (JDP2) is part of the family of stress-responsible transcription factors such as the activation protein-1, and binds the 12-O-tetradecanoylphorbol-13-acetateresponse element and the cAMP response element. It also plays a role as a histone chaperone and participates in diverse processes, such as cell cycle arrest, cell differentiation, apoptosis, senescence, and metastatic spread, and functions as an oncogene and anti-oncogene, and as a cellular reprogramming factor. However, the molecular mechanisms underlying these multiple functions of JDP2 have not been clarified. This review summarizes the structure and function of JDP2, highlighting the specific role of JDP2 in cellular-stress regulation and prevention. (C) 2016 Elsevier B.V. All rights reserved.
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