期刊
GENE
卷 581, 期 2, 页码 139-145出版社
ELSEVIER
DOI: 10.1016/j.gene.2016.01.044
关键词
GPCRs; GPR162; Food intake; Obesity; Glucose homeostasis
资金
- Swedish Research Council
- Ahlens Foundation
- Swedish Brain Research Foundation
- Novo Nordisk Foundation
- Engkvist Foundation
- Magnus Bergvall Foundation
- Novo Nordisk Fonden [NNF15OC0016184, NNF12OC1016287, NNF13OC0005723] Funding Source: researchfish
G protein-coupled receptors (GPCRs) are a class of integral membrane proteins mediating intercellular interactions of fundamental physiological importance for survival including regulation of food intake, blood pressure, and hormonal sensing signaling, among other roles. Homeostatic alterations in the physiological status of GPCRs are often associated with underlying causes of disease, and to date, several orphan GPCRs are still uncharacterized. Findings from our previous study demonstrate that the Rhodopsin family protein GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in hypothalamus, amygdala, and ventral tegmental area, regions strictly interconnected and involved in the regulation of energy homeostasis and hedonic feeding. In this study, we provide a further anatomical characterization of GPR162 in mouse brain via in situ hybridization as well as detailed mRNA expression in a panel of rat tissues complementing a specie-specific mapping of the receptor. We also provide an attempt to demonstrate a functional implication of GPR162 in food intake-related behavior via antisense knockdown studies. Furthermore, we performed human genetic studies in which for the first time, variants of the GPR162 gene were associated with impairments in glucose homeostasis. (C) 2016 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据