4.6 Article

Pentamethinium Salts Nanocomposite for Electrochemical Detection of Heparin

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MATERIALS
卷 14, 期 18, 页码 -

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MDPI
DOI: 10.3390/ma14185357

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gold nanoparticles; gamma-substituted pentamethinium salts; nanocomposite; voltammetric sensor; heparin

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  1. specific university research (MSMT)
  2. UNCE [204064]

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This study introduces a simple method for heparin detection using supramolecular principles and nanomaterials. A voltammetric sensor is developed by depositing AuNPs and PMS nanocomposites on an electrode surface and covering them with a PVC membrane, enabling detection of heparin with a recovery rate of 95.1-100.9%.
This study presents a simple route to heparin detection and develops a voltammetric approach using supramolecular principles and nanomaterials. Nanocomposites, including gold nanoparticles (AuNPs) and gamma-substituted pentamethinium salts (PMS) deposited on a glass carbon (GC) electrode surface (GC/AuNPs/PMS) and covered by a plasticized poly(vinyl chloride) (PVC) membrane, are proposed for heparin detection. The conductivity of the nonconducting PVC-plasticized membrane is guaranteed by AuNPs, and the selectivity is provided by the interaction between gamma-substituted PMS and anionic analytes. In order to extend the linear range, it is necessary to apply a solvent compatible with PVC-plasticized membrane, namely tetrahydrofuran. The proposed voltammetric sensor showed a concentration dependence from 1.72 up to 45.02 IU mL(-1) heparin and was used for heparin detection in saline and biological samples with recovery of 95.1-100.9%.

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