期刊
JOURNAL OF COSMETIC DERMATOLOGY
卷 21, 期 4, 页码 1651-1655出版社
WILEY
DOI: 10.1111/jocd.14264
关键词
acne vulgaris; resistin gene (-420 C > G) polymorphism
类别
This study found a significant association between resistin gene (-420 C > G) polymorphism and acne vulgaris risk, with the CG genotype showing a protective role and potentially linked to a reduced risk of acne vulgaris development. Further research is needed to confirm these findings in other populations.
Background Acne vulgaris (AV) is the most prevalent inflammatory skin disease and develops on the face and upper trunk. Resistin, a member of the cysteine-rich secretory proteins family, is an adipokine expressed primarily in macrophages and monocytes; it has a role to play in the inflammatory period. Aims This study's purpose was to detect whether known resistin gene (-420 C > G) polymorphism plays a role in the pathogenesis of AV. Methods Patients with AV (n = 94) and healthy controls (n = 94) were enrolled in this investigation. Resistin gene (-420 C > G) polymorphism was decided by PCR-RFLP procedure. Results The distribution of genotype frequencies of resistin gene (-420 C > G) polymorphism was significantly different between the AV and healthy controls (p = 0.002). We found that the resistin gene (-420 C > G) CG genotype exhibited a significant association with decreased acne vulgaris risk. Conclusions Our study is the first report investigating the relationship between the risk of AV and resistin gene (-420 C > G) polymorphism in the Turkish population. Resistin gene (-420 C > G) polymorphism is related to AV pathogenesis. CG genotype has a protective role and may be linked to a reduced risk of AV development. Furthermore, studies are needed to verify these findings in other populations.
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