Evaluation of serum insulin-like growth factor-1, insulin, glucose levels in patients with adolescent and post-adolescent acne

Objectives There are many endogenous and exogenous factors that cause acne formation. This study aimed to determine whether the acne severity in patients with various age ranges is associated with serum insulin-like growth factor, insulin, and glucose and to identify how much they affect the acne severity. Materials and Methods In this case-control prospective study, 44 patients with acne vulgaris and 44 age- and gender-matched control subjects without acne were evaluated. Patients and the control group were divided into two age-groups as adolescence and post-adolescence. According to the Global Acne Scoring System (GASS) of the acne group, the acne score grades between 0 and 44 were calculated. The correlations between the IGF-1, insulin, glucose levels, and acne grades were calculated in each group. Results In our study, the acne scores and serum IGF-1 levels were found to be significantly higher in patients under the age of 21 than patients over the age of 21. There was a statistically significant difference in acne score between the two groups. However, there was no statistically significant difference between the serum IGF-1, insulin, and glucose levels of the acne group and the control group. Conclusion In this study, it has been revealed that IGF-1 is effective at the pathogenesis of acne in adolescence.

Automated summary

The study revealed that acne severity and serum IGF-1 levels are significantly higher in patients under the age of 21 compared to patients over the age of 21. However, there was no significant difference in the serum IGF-1, insulin, and glucose levels between the acne group and the control group.