B-cell compartment abnormalities are associated with ACLF and mortality in patients with liver cirrhosis

Background: Liver cirrhosis profoundly affects the immune system, leading to an immunological imbalance known as cirrhosis-associated immune dysfunction. Aims: This study aimed to investigate B-cell disturbances in patients with acute decompensation (AD) of cirrhosis and assess relationships with prognosis and mortality. Methods: The study included 39 patients with AD of cirrhosis, 29 patients with stable cirrhosis (SC), and 30 healthy controls (CTR). Circulating B-cell subsets and cytokine plasma levels were determined by flow cytometry.

Automated summary

This study investigated B-cell disturbances in patients with acute decompensation of cirrhosis and found potential relationships with prognosis and mortality.