Non-invasive diagnosis and follow-up in liver transplantation

The field of liver transplantation directly or indirectly embodies all liver diseases, in addition to specific ones related to organ rejection (cellular and humoral). The recommended non-invasive methods for determining the indication for liver transplantation are the Model for End-stage Liver Disease score, and the alpha-foetoprotein score in case of hepatocellular carcinoma. Radiological methods are the cornerstones for the diagnosis of vascular and biliary complications after liver transplantation. The possible diseases of the liver graft after transplantation are multiple and often intertwined. Non-invasive diagnostic methods have been poorly evaluated in this context, apart from the recurrence of hepatitis C. Liver biopsy remains the gold standard for evaluating graft lesions in the majority of cases, especially graft rejection. (C) 2021 Published Elsevier Masson SAS.

Automated summary

Liver transplantation encompasses a wide range of diseases, with diagnosis mainly relying on MELD score and alpha-fetoprotein score for hepatocellular carcinoma. Radiological methods are used for post-transplantation complication diagnosis, while liver biopsy remains the gold standard for evaluating graft lesions.