期刊
BIOMEDICAL OPTICS EXPRESS
卷 12, 期 9, 页码 5704-5719出版社
Optica Publishing Group
DOI: 10.1364/BOE.428101
关键词
COVID-19; SARS-CoV-2; Vaccines; Autoimmunity; BNT162b2
资金
- Fonds de Recherche du Quebec -Sante [32600]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-06404-2016, RGPIN-2015-04672, RGPIN-2018-06151, RTI-2016-00636]
A new method for FM-OCT based on an all-fiber system with MSPL for parallel modal demultiplexing is introduced, providing the robustness required for clinical applications. The article also presents a comprehensive coupling model for the interpretation of FM-OCT images and validates the technique through experiments.
Optical coherence tomography (OCT) was recently performed using a few-mode (FM) fiber to increase contrast or improve resolution using a sequential time-domain demultiplexing scheme isolating the different interferometric signals of the mode-coupled backscattered light. Here, we present an all-fiber FM-OCT system based on a parallel modal demultiplexing scheme exploiting a novel modally-specific photonic lantern (MSPL). The MSPL allows for maximal fringe visibility for each fiber propagation mode in an all-fiber assembly which provides the robustness required for clinical applications. The custom-built MSPL was designed for OCT at 930 nm and is wavelength-independent over the broad OCT spectrum. We further present a comprehensive coupling model for the interpretation of FM-OCT images using the first two propagation modes of a few-mode fiber, validate its predictions, and demonstrate the technique using in vitro microbead phantoms and ex vivo biological samples.
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