4.6 Article

Photoacoustic computed tomography of mechanical HIFU-induced vascular injury

期刊

BIOMEDICAL OPTICS EXPRESS
卷 12, 期 9, 页码 5489-5498

出版社

OPTICAL SOC AMER
DOI: 10.1364/BOE.426660

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资金

  1. National Institutes of Health [R01 EB028143, R01 NS111039, R21 EB027304, R21EB027981, R43 CA239830, R43 CA243822, R44 HL138185, RF1 NS115581]
  2. Duke Institute for Brain Sciences, Duke University
  3. American Heart Association [18CSA34080277]
  4. Chan Zuckerberg Initiative [2020-226178]

向作者/读者索取更多资源

The study developed an integrated HIFU-PACT system for detecting vascular rupture in mechanical HIFU treatment. They demonstrated the use of singular value decomposition to enhance hemorrhage detection and validated the system's performance on phantoms and in vivo animal tumor models. This PACT-HIFU system is expected to have practical applications in oncology research using small animal models.
Mechanical high-intensity focused ultrasound (HIFU) has been used for cancer treatment and drug delivery. Existing monitoring methods for mechanical HIFU therapies such as MRI and ultrasound imaging often suffer from high cost, poor spatial-temporal resolution, and/or low sensitivity to tissue's hemodynamic changes. Evaluating vascular injury during mechanical HIFU treatment, therefore, remains challenging. Photoacoustic computed tomography (PACT) is a promising tool to meet this need. Intrinsically sensitive to optical absorption, PACT provides high-resolution imaging of blood vessels using hemoglobin as the endogenous contrast. In this study, we have developed an integrated HIFU-PACT system for detecting vascular rupture in mechanical HIFU treatment. We have demonstrated singular value decomposition for enhancing hemorrhage detection. We have validated the HIFU-PACT performance on phantoms and in vivo animal tumor models. We expect that PACT-HIFU will find practical applications in oncology research using small animal models. (c) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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