期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 14, 期 7, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.arabjc.2021.103236
关键词
Chromium(III) complex; Metformin; Diabetes mellitus; Bioactivity
资金
- National Natural Science Foundation of PR China [21571117, 21701121]
- Natural Science Foundation of Shanxi Province [201801D121064]
- Science and Technology Innovation Project of Colleges and Universities in Shanxi Province [2020L0585]
- Innovation Project for College Students in Shanxi Province [2020491]
The study synthesized a chromium(III) complex, characterized its structure, evaluated its bioactivities and toxicity, revealing that the complex has beneficial effects on T2DM and is safe for organisms.
The chromium(III) complex, Cr(C7H3NO4)(2)center dot C4H12N5 (1), was synthesised by chelating chromium with dipicolinic (H(2)dipic) in methanol, and its structure was characterised using elemental analysis (EA), spectroscopy (infrared, UV-visible, and fluorescence) and single-crystal X-ray method. The density functional theoretical (DFT) computation was performed using the Gaussian 09 package. The stability of solution at different temperatures and pH values, the electrochemical, morphological and thermal properties of complex 1 were discussed. The preliminary bioactivities of complex 1 in streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) mice were investigated using daily oral gavage for 12 weeks. The cytotoxicity was assessed using the methyl thiazolyl tetrazolium (MTT) assays, and the acute toxicity experiment test was carried out on healthy C57BL/6 mice with this complex. The complex 1 crystallised in the monoclinic system with the space group P2(1)/n, R1 = 0.0642. The DFT-optimised structure of complex 1 was in excellent agreement with the X-ray crystal structure. The complex 1 exhibited good physical and chemical properties and beneficial function on blood glucose and lipid metabolism for T2DM. The antidiabetic activity of chromium(III) might be associated with chromium(VI). Furthermore, the cytotoxicity and the acute toxicity experiments showed that the complex 1 was hypotonic and secure to organism. The study of complex 1 showed that the prepared complex on the basis of H2dipic and Met could inhibit hyperglycaemia and hyperlipidaemia in vivo and did not have potential toxicity. These results demonstrated that the complex 1 might provide an important reference for the development of functional hypoglycaemic foods or pharmaceuticals of T2DM. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
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