期刊
AESTHETIC SURGERY JOURNAL
卷 41, 期 10, 页码 NP1323-NP1336出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/asj/sjab231
关键词
-
类别
资金
- Chang Gung Memorial Hospital (Taoyuan City, Taiwan) [CMRPG3H1071]
The study found that VASER liposuction method resulted in more angiogenesis and less fibrosis in the grafted fat tissue compared to traditional suction-assisted liposuction (TSAL). Furthermore, VASER-derived ASCs showed better quality in terms of cell differentiation capacity.
Background: Recently, there has been increasing research interest in identifying the effect of liposuction procedures on fat graft survival in order to clarify whether different harvest techniques affect the quality of fat grafts. Objectives: The aim of this study was to investigate the effect of 2 liposuction methods on the survival and regeneration potential of grafted fat tissue. The proliferation and differentiation potentials of adipose-derived stem cells (ASCs) isolated by both methods was also investigated. Methods: Fat grafts were collected from patients who underwent liposuction procedures by 2 different methods: traditional suction-assisted liposuction (TSAL) and vibration amplification of sound energy at resonance (VASER). One portion of the lipoaspirates was implanted into the subcutaneous layer of nu mice for 4 and 12 weeks. ASCs were isolated from the other portion of the lipoaspirate and subjected to proliferation and differentiation assays. Results: Although in vivo fat grafting presented similar adipose tissue survival for the 2 different liposuction methods, more angiogenesis and less fibrosis was observed in the VASER group based on histologic evaluation. Furthermore, VASER-derived ASCs presented better quality in terms of cell differentiation capacity. Conclusions: The in vivo study confirmed better graft angiogenesis with less inflammation, apoptosis, and scar formation in the VASER group. ASCs harvested with VASER exhibited increased differentiation capacity compared with those obtained by TSAL, and represent an excellent source for fat grafting and regenerative medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据