期刊
ACS CATALYSIS
卷 11, 期 19, 页码 12375-12383出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.1c03603
关键词
C-H activation; annulation; rhodium; indoline; vinylsilane
资金
- MEXT [17H06091]
- Naito Foundation
- Grants-in-Aid for Scientific Research [17H06091] Funding Source: KAKEN
The Rh(III)-catalyzed reaction of aniline derivatives containing a pyrimidine directing group with vinylsilanes leads to the formation of C3-substituted indoline derivatives via a highly regioselective C-H activation/alkene cyclization cascade. Mechanistic experiments suggest that C-H bond cleavage is not the rate-determining step, but rather the reaction proceeds through the formation of a six-membered rhodacycle as a key catalytic species via pyrimidine-directed electrophilic ortho-C-H rhodation.
The Rh(III)-catalyzed reaction of aniline derivatives that contain a pyrimidine directing group with vinylsilanes results in the formation of C3-substituted indoline derivatives in a highly regioselective manner via a C-H activation/alkene cyclization cascade. The results of the mechanistic experiments indicate that C-H bond cleavage is not the rate-determining step and that the reaction proceeds via the formation of a six-membered rhodacycle as a key catalytic species through a pyrimidine-directed electrophilic ortho-C-H rhodation.
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