期刊
ACS CATALYSIS
卷 11, 期 15, 页码 9715-9721出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.1c02890
关键词
dual catalysis relay; cross-dehydrogenative coupling; NHC catalysis; visible-light catalysis; radical-radical coupling
资金
- NSFC [21971101, 21801126]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011976]
- Pearl River Talent Recruitment Program [2019QN01Y261]
- Thousand Talents Program for Young Scholars
- Stable Support Plan Program of Shenzhen Natural Science Fund [20200925152608001]
- Guangdong Provincial Key Laboratory of Catalysis [2020B121201002]
This translation describes a method of intermolecular vinylation of aldehydes using alkenes as the vinylating reagents through sequential two-fold C-H functionalizations and a dual catalysis relay enabled cross-dehydrogenative coupling mechanism.
Direct functionalizations of two distinct inert C-H bonds represent the most ideal ways to construct C-C bonds. Herein, we report an intermolecular vinylation of aldehydes using alkenes as the vinylating reagents through sequential two-fold C-H functionalizations. The merging of visible light and N-heterocyclic carbene catalysis allows for the coupling of alkenes with aldehydes through a dual catalysis relay enabled cross-dehydrogenative coupling mechanism. The use of diphenoquinone is essential for the success of this reaction, which plays an intriguing two-fold role in the reaction, as an electron acceptor as well as a radical reservoir for the radical coupling enabling the C-C forming process.
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