期刊
ACS CATALYSIS
卷 11, 期 14, 页码 8942-8947出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.1c02277
关键词
C-C bond cleavage; ring-closing/ring-opening reaction; dicarbofunctionalization; unactivated alkenes; asymmetric Pd-catalysis
资金
- National Natural Science Foundation of China [21572126, 22001161]
- Technicians Troop Construction Projects of Henan Province [C20150030]
- Program of Science and Technology Innovation Talents of Henan Province [184100510011]
A Pd-catalyzed chemo-, regio-, and enantioselective ring-closing/ring-opening cross coupling reaction has been developed with diverse aryl halide-tethered alkenes and benzocyclobutenols as substrates. This method provides a convenient approach to chiral 2,3-dihydrobenzofurans with excellent enantioselectivities, and has been applied in the concise synthesis of analogues of cannabinoid receptor 2 agonists.
Pd-catalyzed chemo-, regio-, and enantioselective ring-closing/ring-opening cross coupling reaction has been developed with diverse aryl halide-tethered alkenes and benzocyclobutenols as substrates, which renders the highly enantioselective diarylation of unactivated alkenes and provides a convenient method toward chiral 2,3-dihydrobenzofurans bearing a quaternary stereocenter with excellent enantioselectivities (up to 98% ee). The application in concise synthesis of the analogue of cannabinoid receptor 2 agonists is described.
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