期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-25312-0
关键词
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资金
- National Natural Science Foundation of China [81670536, 81770593, 82061138006]
- National Grand Program on Key Infectious Disease Control [2017ZX10202203-004-002, 2018ZX10301404-003-002]
- Guangdong Provincial Department of Science and Technology Fund [2020B1111330002]
- Guangzhou Health Science and Technology Program [20211A010029]
- Sino-German Center for Research Promotion(SGC)'s Rapid Response Funding Call for Bilateral Collaborative Proposals Between China and Germany in COVID-19 Related Research [C-0032]
- Emergency Key Program of Guangzhou Laboratory [EKPG21-29]
The study found that SARS-CoV-2 specific immune response can persist to some extent up to 1 year after recovery from COVID-19, with serum neutralizing capacity decreasing but remaining stable. Viral-specific cellular immune protection persists between 6 months and 12 months after recovery.
SARS-CoV-2 vaccination has been launched worldwide to build effective population-level immunity to curb the spread of this virus. The effectiveness and duration of protective immunity is a critical factor for public health. Here, we report the kinetics of the SARS-CoV-2 specific immune response in 204 individuals up to 1-year after recovery from COVID-19. RBD-IgG and full-length spike-IgG concentrations and serum neutralizing capacity decreases during the first 6-months, but is maintained stably up to 1-year after hospital discharge. Even individuals who had generated high IgG levels during early convalescent stages had IgG levels that had decreased to a similar level one year later. Notably, the RBD-IgG level positively correlates with serum neutralizing capacity, suggesting the representative role of RBD-IgG in predicting serum protection. Moreover, viral-specific cellular immune protection, including spike and nucleoprotein specific, persisted between 6 months and 12 months. Altogether, our study supports the persistence of viral-specific protective immunity over 1 year. The quality of immune response to SARS-CoV-2 is thought to wane over time, but it is unclear how long it can persist. Here the authors show persistent immune responses in a large number of patients over the course of a 1-year follow-up from the time of recovery from COVID-19.
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