Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.

Automated summary

Recent studies have shown additional mechanisms behind cystine starvation-induced ferroptosis, apart from impaired GSH synthesis, highlighting the importance of the cyst(e)ine/glutathione/glutathione peroxidase 4 (GPX4) axis in triggering ferroptosis and inhibiting tumor growth.