期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41467-021-24311-5
关键词
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资金
- NWO [823-02-010]
- European Union [7202070, 339490]
- Stichting Vrienden van het Herseninstituut
- Radboud Excellence Initiative
- Wellcome Trust
- Royal Society [211258/Z/18/Z]
- Wellcome Trust [211258/Z/18/Z] Funding Source: Wellcome Trust
The study reveals a region in mouse visual cortex with smaller population receptive-fields, representing a location in space directly in front and slightly above the mouse, indicating a non-uniform representation of space in mouse visual cortex.
The representation of space in mouse visual cortex was thought to be relatively uniform. Here we reveal, using population receptive-field (pRF) mapping techniques, that mouse visual cortex contains a region in which pRFs are considerably smaller. This region, the focea, represents a location in space in front of, and slightly above, the mouse. Using two-photon imaging we show that the smaller pRFs are due to lower scatter of receptive-fields at the focea and an over-representation of binocular regions of space. We show that receptive-fields of single-neurons in areas LM and AL are smaller at the focea and that mice have improved visual resolution in this region of space. Furthermore, freely moving mice make compensatory eye-movements to hold this region in front of them. Our results indicate that mice have spatial biases in their visual processing, a finding that has important implications for the use of the mouse model of vision. The representation of space in mouse visual cortex was considered to be relatively uniform. The authors show that mice have improved visual resolution in a cortical region representing a location in space directly in front and slightly above them, showing that the representation of space in mouse visual cortex is non-uniform.
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