4.8 Article

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52

Elodie Hatchi et al.

Summary: Strong connections are found between R-loops, genome instability, and human disease. R-loops play a role in maintaining homeostasis by regulating certain physiological processes, such as the synthesis of antisense transcripts through transcription termination pause sites. A species of single-stranded, DNA-damage-associated small RNA (sdRNA) generated by a BRCA1-RNAi complex promotes DNA repair at transcriptional termination pause sites forming R-loops.

NATURE (2021)

Review Biochemistry & Molecular Biology

The DNA secondary structures at telomeres and genome instability

Jun Tan et al.

CELL AND BIOSCIENCE (2020)

Article Biochemistry & Molecular Biology

BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells

Huai-Chin Chiang et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

Yong Woo Lee et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

Yong Woo Lee et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Review Cell Biology

Telomeres in cancer: tumour suppression and genome instability

John Maciejowski et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

Xiaolei Pan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemical Research Methods

multiplierz v2.0: A Python-based ecosystem for shared access and analysis of native mass spectrometry data

William M. Alexander et al.

PROTEOMICS (2017)

Article Multidisciplinary Sciences

Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences

Laetitia Maestroni et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

Shira Sagie et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

Xiaowen Zhang et al.

NATURE COMMUNICATIONS (2017)

Review Oncology

Trabectedin as a chemotherapy option for patients with BRCA deficiency

Bradley J. Monk et al.

CANCER TREATMENT REVIEWS (2016)

Article Multidisciplinary Sciences

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage

Sarah J. Hill et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Correction Biochemistry & Molecular Biology

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres (vol 34, pg 410, 2015)

Sophie Badie et al.

EMBO JOURNAL (2015)

Article Biochemistry & Molecular Biology

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

Elodie Hatchi et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

Rachel Litman Flynn et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence

Maja Sedic et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells

Samir Acharya et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

Rajika Arora et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

Ylli Doksani et al.

Article Biochemistry & Molecular Biology

Regulation of Telomere Length by G-Quadruplex Telomere DNA- and TERRA-Binding Protein TLS/FUS

Kentaro Takahama et al.

CHEMISTRY & BIOLOGY (2013)

Article Biochemistry & Molecular Biology

The heterochromatic chromosome caps in great apes impact telomere metabolism

Clara Novo et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Biochemistry & Molecular Biology

Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair

Sophie E. Polo et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

Paul A. Ginno et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

Nausica Arnoult et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Transcription regulates telomere dynamics in human cancer cells

Rajika Arora et al.

Article Biochemistry & Molecular Biology

STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1

Serena L. Clark et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2012)

Article Biochemistry & Molecular Biology

ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation

Shizhou Liu et al.

MOLECULAR CELL (2011)

Article Biochemistry & Molecular Biology

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

Konstantina Skourti-Stathaki et al.

MOLECULAR CELL (2011)

Review Genetics & Heredity

Alternative lengthening of telomeres: models, mechanisms and implications

Anthony J. Cesare et al.

NATURE REVIEWS GENETICS (2010)

Article Multidisciplinary Sciences

TERRA transcripts are bound by a complex array of RNA-binding proteins

Isabel Lopez de Silanes et al.

NATURE COMMUNICATIONS (2010)

Article Biochemistry & Molecular Biology

BRCA1 Localization to the Telomere and Its Loss from the Telomere in Response to DNA Damage

Rahul D. Ballal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

Zhong Deng et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

CpG-island promoters drive transcription of human telomeres

Solomon G. Nergadze et al.

Article Cell Biology

The telomeric transcriptome and SMG proteins at the crossroads

R. Chawla et al.

CYTOGENETIC AND GENOME RESEARCH (2008)

Article Multidisciplinary Sciences

Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends

Claus M. Azzalin et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

Homologous recombination generates T-loop-sized deletions at human telomeres

RC Wang et al.

Article Biochemistry & Molecular Biology

BRCA1 inhibition of telomerase activity in cultured cells

JB Xiong et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

H Zhao et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

In vitro properties of the conserved mammalian protein hnRNP D suggest a role in telomere maintenance

A Eversole et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)