期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-25509-3
关键词
-
资金
- Stanford Maternal and Child Health Research Institute postdoctoral fellowship
- Stanford University
- Vice Provost for Undergraduate Education's (VPUE) 2019-2020 Major Grant
- Carreras Foundation [AH 06-01]
- Universities Giessen and Marburg Lung Center
- German Center for Lung Research
- University Hospital Giessen and Marburg (UKGM)
- Deutsche Forschungsgemeinschaft (DFG) [SFB 1021, KFO 309, SK 317/1-1, 428518790]
- Foundation for Pathobiochemistry and Molecular Diagnostics
- NIH [AI105343, AI112521, AI082630, AI201085, AI123539, AI117950, UC4 DK112217, UM1-AI144288, PA30CA016520, P30-AI0450080, HL137006, HL137915, U01 AI150741-01S1]
- Parker Institute for Cancer Immunotherapy
- National Institute of Allergy and Infectious Disease (NIAID/NIH)
- Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania
- Stiftung P.E. Kempkes
- Deutsche Jose Carreras Leukamie-Stiftung [18 R/2016]
- Rhon Klinikum AG (RKA) [64]
- Universities Giessen Marburg Lung Center
- German Center for Lung Disease (DZL German Lung Center) [82DZL00502]
- UTHSC/UofM SARS-CoV-2/COVID-19 Research CORNET Award
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01 AI125197-04, R01 AI139119, U19 AI111825, U54 CA260517]
- Henry Gustav Floren Trust
- Chan Zuckerberg Biohub
- Searle Scholars Program
- Fast Grants
- CEND COVID Catalyst Fund
- [T32 HL007586]
In hospitalized COVID-19 patients, approximately 50% have detectable autoantibodies primarily targeting autoantigens associated with rare disorders. Additionally, a subset of autoantibodies develop de novo following SARS-CoV-2 infection.
COVID-19 is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. Here we develop three protein arrays to measure IgG autoantibodies associated with connective tissue diseases, anti-cytokine antibodies, and anti-viral antibody responses in serum from 147 hospitalized COVID-19 patients. Autoantibodies are identified in approximately 50% of patients but in less than 15% of healthy controls. When present, autoantibodies largely target autoantigens associated with rare disorders such as myositis, systemic sclerosis and overlap syndromes. A subset of autoantibodies targeting traditional autoantigens or cytokines develop de novo following SARS-CoV-2 infection. Autoantibodies track with longitudinal development of IgG antibodies recognizing SARS-CoV-2 structural proteins and a subset of non-structural proteins, but not proteins from influenza, seasonal coronaviruses or other pathogenic viruses. We conclude that SARS-CoV-2 causes development of new-onset IgG autoantibodies in a significant proportion of hospitalized COVID-19 patients and are positively correlated with immune responses to SARS-CoV-2 proteins. Infection with SARS-CoV2 and the development of Coronavirus disease 2019 (COVID-19) has been linked to induction of autoimmunity and autoantibody production. Here the authors characterise the new-onset IgG autoantibody response in hospitalised patients with COVID-19 which they correlate to the magnitude of the SARS-CoV2 response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据