期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-24654-z
关键词
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资金
- Defense Advanced Research Project Agency (DARPA) [HR0011-17-2-0047]
- NIH [R21RAI149161A, R01AI151004, DP2AI152071, R01AI116636]
- UK Biotechnology and Biological Sciences Research Council (BBSRC) [BBS/E/I/00007033]
- DARPA PREEMPT award [HR001118S0017]
- NSF [1645331]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDPB16]
- BBSRC [BBS/E/I/00007033] Funding Source: UKRI
This review explores the latest developments in pathogen-blocking Wolbachia and genome engineering approaches to mosquito-borne disease control, discussing their similarities and critical distinctions, as well as their potential future applications.
Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control. Mosquito-borne diseases pose significant global health burdens. In this review, the authors explore Wolbachia and genome engineering approaches to mosquito-borne disease population control.
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