期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-25435-4
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资金
- US National Institutes of Health (NIH) [R01HG002385]
- NIH Pathway to Independence Award (NHGRI) [K99HG011041]
- National Health and Medical Research Council (NHMRC) C. J. Martin Biomedical Fellowship [1073726]
- National Health and Medical Research Council of Australia [1073726] Funding Source: NHMRC
The study reveals that TRP channel-associated factor 1/2 (TCAF1/TCAF2) proteins antagonistically regulate the cold-sensor protein TRPM8 in human tissues and have undergone duplications and diversification in the process of evolution. Differential TCAF2 expression among human haplogroups and high levels of TCAF2 and TRPM8 expression in the liver and prostate of modern humans are observed.
TRP channel-associated factor 1/2 (TCAF1/TCAF2) proteins antagonistically regulate the cold-sensor protein TRPM8 in multiple human tissues. Understanding their significance has been complicated given the locus spans a gap-ridden region with complex segmental duplications in GRCh38. Using long-read sequencing, we sequence-resolve the locus, annotate full-length TCAF models in primate genomes, and show substantial human-specific TCAF copy number variation. We identify two human super haplogroups, H4 and H5, and establish that TCAF duplications originated similar to 1.7 million years ago but diversified only in Homo sapiens by recurrent structural mutations. Conversely, in all archaic-hominin samples the fixation for a specific H4 haplotype without duplication is likely due to positive selection. Here, our results of TCAF copy number expansion, selection signals in hominins, and differential TCAF2 expression between haplogroups and high TCAF2 and TRPM8 expression in liver and prostate in modern-day humans imply TCAF diversification among hominins potentially in response to cold or dietary adaptations.
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