4.8 Article

RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection

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NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -

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NATURE RESEARCH
DOI: 10.1038/s41467-021-23588-w

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资金

  1. Knut and Alice Wallenberg Foundation [2016.0063]
  2. Swedish Research Council [2018-02855]
  3. Insamlingsstiftelsen, Medical Faculty at Umea University
  4. Novo Nordisk Foundation [NNF17OC0026486]
  5. ERC [716063]
  6. Academy of Finland Research Fellow Grant [317680]
  7. Swedish Research Council [2018-02855] Funding Source: Swedish Research Council
  8. Vinnova [2018-02855] Funding Source: Vinnova
  9. European Research Council (ERC) [716063] Funding Source: European Research Council (ERC)

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In this study, Avican et al. presented global transcriptomes for 32 bacterial pathogens grown under 11 stress conditions, identifying common and unique regulatory responses, as well as processes participating in different stress responses. Bacterial stress responses are potential targets for new antimicrobials.
Bacterial processes necessary for adaption to stressful host environments are potential targets for new antimicrobials. Here, we report large-scale transcriptomic analyses of 32 human bacterial pathogens grown under 11 stress conditions mimicking human host environments. The potential relevance of the in vitro stress conditions and responses is supported by comparisons with available in vivo transcriptomes of clinically important pathogens. Calculation of a probability score enables comparative cross-microbial analyses of the stress responses, revealing common and unique regulatory responses to different stresses, as well as overlapping processes participating in different stress responses. We identify conserved and species-specific 'universal stress responders', that is, genes showing altered expression in multiple stress conditions. Non-coding RNAs are involved in a substantial proportion of the responses. The data are collected in a freely available, interactive online resource (PATHOgenex). Bacterial stress responses are potential targets for new antimicrobials. Here, Avican et al. present global transcriptomes for 32 bacterial pathogens grown under 11 stress conditions, and identify common and unique regulatory responses, as well as processes participating in different stress responses.

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