期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-24680-x
关键词
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资金
- Natural Science Foundation of China [81671832, 81571826]
- Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [826158]
- National Key Research and Development Programmes for Acute Aortic Syndrome in High-risk Early-warning and Intervention [2017YFC1308000]
- Natural Science Foundation of Shanghai [18ZR1401900]
- Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-dimension Materials (Donghua University) [18520750400]
- Fundamental Research Funds for the Central Universities, DHU Distinguished Young Professor Programme [LZA2019001]
The unique properties of self-healing materials in the field of biomedical engineering hold great potential. By designing and applying biodegradable and biocompatible self-healing elastomers to various disease models in vivo, their reparative potential in situations such as aortic aneurysm, nerve coaptation, and bone immobilization has been validated in animal models, indicating promising therapies.
The unique properties of self-healing materials hold great potential in the field of biomedical engineering. Although previous studies have focused on the design and synthesis of self-healing materials, their application in in vivo settings remains limited. Here, we design a series of biodegradable and biocompatible self-healing elastomers (SHEs) with tunable mechanical properties, and apply them to various disease models in vivo, in order to test their reparative potential in multiple tissues and at physiological conditions. We validate the effectiveness of SHEs as promising therapies for aortic aneurysm, nerve coaptation and bone immobilization in three animal models. The data presented here support the translation potential of SHEs in diverse settings, and pave the way for the development of self-healing materials in clinical contexts. The unique properties of self-healing materials hold great potential in the field of biomedical engineering. Here, the authors designed a series of biodegradable and biocompatible self-healing elastomers with tunable mechanical properties, and apply them to various disease models in vivo, including aortic aneurism, bone fracture and nerve amputation.
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