4.4 Article

CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression

期刊

ONCOLOGY LETTERS
卷 22, 期 2, 页码 -

出版社

SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2021.12848

关键词

C-X-C motif chemokine receptor 4; vascular endothelial growth factor; gastric cancer; prognosis; migration; invasion

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资金

  1. National Natural Science Foundation of China [81773944]
  2. Young Medicine Focus Talent Foundation of Jiangsu Province [QNRC2016206]
  3. Postgraduate Research by Practice Innovation Program of Jiangsu Province [KYCX18_ 2382]
  4. Top Talent Support Program for young and middle-aged people of Wuxi Health Committee [2017]
  5. Wuxi City Health Planning Commission project [MS201815, Z201907]
  6. Natural Science Foundation of Jiangsu Province [BK20191149]

向作者/读者索取更多资源

This study found that CXCR4 and VEGF play important roles in predicting the prognosis of patients with gastric cancer, affecting survival rates by regulating cell invasive and migratory abilities. Additionally, their high expression is associated with poorer overall survival and are independent negative biomarkers.
Metastasis is the main cause of poor prognosis of patients with gastric cancer (GC). Thus, current research is focused on identifying biomarkers that can predict the prognosis of patients with GC. C-X-C motif chemokine receptor 4 (CXCR4) and vascular endothelial growth factor (VEGF) have been reported to play important roles in different types of malignancies; however, their role in the prognosis of GC remains unknown. The present study aimed to investigate the potential role of CXCR4 and VEGF in predicting the prognosis of patients with GC. Immunohistochemistry analysis was performed to analyze the expression levels of CXCR4 and VEGF in a GC tissue microarray containing GC tissues and adjacent normal tissues. The association between CXCR4 or VEGF expression levels and the clinicopathological characteristics or survival outcomes were assessed. Furthermore, Transwell and wound healing assays were performed to determine the cell invasive and migratory abilities in vitro. The results demonstrated that CXCR4 promoted AGS cell invasion and migration by regulating VEGF expression. In addition, CXCR4 and VEGF expression levels were significantly upregulated in GC tissues compared with adjacent normal tissues, which was associated with a poorer overall survival (OS). Cox regression analysis demonstrated that both upregulated CXCR4 and VEGF expression were independent negative biomarkers of OS. To the best of our knowledge, the present study was the first to discover that CXCR4 and VEGF exert synergistic roles as efficient prognostic indicators for patients with GC.

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