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External cervical resorption-a review of pathogenesis and potential predisposing factors

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DOI: 10.1038/s41368-021-00121-9

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  1. Beijing Municipal Natural Science Foundation [7182185]

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External cervical resorption (ECR) is a pathological condition where resorption tissues invade the cervical aspect of the root, causing severe damage to dental tissue and potentially involving the pulp. The etiology of ECR is poorly understood, and timely diagnosis and treatment are crucial. Research on histopathology and pathogenesis has shed light on potential mechanisms of ECR.
External cervical resorption (ECR) refers to a pathological state in which resorption tissues penetrate into the dentin at the cervical aspect of the root. Despite being latent in its initial phase, ECR could cause severe damage to mineralized dental tissue and even involve the pulp if not given timely diagnosis and treatment. Nevertheless, the etiology of ECR is still poorly understood, which adds to the difficulty in early diagnosis. ECR has received growing attention in recent years due to the increasing number of clinical cases. Several potential predisposing factors have been recognized in cross-sectional studies as well as case reports. In the meantime, studies on histopathology and pathogenesis have shed light on possible mechanisms of ECR. This review aims to summarize the latest findings in the pathogenesis and potential predisposing factors of ECR, so as to provide pragmatic reference for clinical practice.

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