期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 14, 期 2, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a040113
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资金
- NIH [R01GM132427, R25GM109441]
Lamins interact with various nuclear membrane proteins, transcription factors, chromatin regulators, signaling molecules, and chromatin itself to form a nuclear subcompartment called the nuclear lamina, which plays important roles in nuclear integrity, cellular positioning, mitosis, DNA repair, and gene regulation. Lamins also interact with lamin-associated peptides and peripheral heterochromatin domains, contributing to dynamic 3D genome organization and the expression of developmentally regulated genes.
Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear subcompartment, the nuclear lamina, that is involved in a variety of cellular processes such as the governance of nuclear integrity, nuclear positioning, mitosis, DNA repair, DNA replication, splicing, signaling, mechanotransduction and -sensation, transcriptional regulation, and genome organization. Lamins are the primary scaffold for this nuclear subcompartment, but interactions with lamin-associated peptides in the inner nuclear membrane are self-reinforcing and mutually required. Lamins also interact, directly and indirectly, with peripheral heterochromatin domains called lamina-associated domains (LADs) and help to regulate dynamic 3D genome organization and expression of developmentally regulated genes.
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