期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 14, 期 1, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a039685
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资金
- Helsinki Institute of Life Science
- Juselius Foundation
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [770877-STEMpop]
- EMBO Long-Term fellowship [ALTF 7282017]
- EMBO Human Frontier Science Program [LT000861/2018]
- Wihuri Research Institute
- Academy of Finland
Cells generate and sense mechanical forces to control cell fate and maintain genome integrity.
Cells generate and sense mechanical forces that trigger biochemical signals to elicit cellular responses that control cell fate changes. Mechanical forces also physically distort neighboring cells and the surrounding connective tissue, which propagate mechanochemical signals over long distances to guide tissue patterning, organogenesis, and adult tissue homeostasis. As the largest and stiffest organelle, the nucleus is particularly sensitive to mechanical force and deformation. Nuclear responses to mechanical force include adaptations in chromatin architecture and transcriptional activity that trigger changes in cell state. These force-driven changes also influence the mechanical properties of chromatin and nuclei themselves to prevent aberrant alterations in nuclear shape and help maintain genome integrity. This review will discuss principles of nuclear mechanotransduction and chromatin mechanics and their role in DNA damage and cell fate regulation.
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