期刊
JOURNAL OF FUNCTIONAL FOODS
卷 84, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2021.104597
关键词
Mankai (R); Wolffia globosa; Polyphenols; Microbiota; Batch culture; Short chain fatty acids
资金
- Hinoman Ltd., (Hevel Shalom, Israel)
- Nutrition and Nutrigenomic Unit, Fondazione Edmund Mach
- JPI-HDHL project CABALA_diet&health (ERA-Net Cofund) [ERA-HDHL N696295]
The study found that Mankai (R) significantly stimulated the metabolic activity of the gut microbiota and reduced microbial diversity, indicating its potential impact on health through selective modulation of microbiome composition.
Mankai (R) is a cultivated strain of Wolffia globosa an aquatic plant of the family Lemnaceae commonly known as Duckweeds. Recent studies suggest that consumption of a Mankai (R) enriched diet may provide positive health effects by decreasing body weight and improving glucose homeostasis and plasma lipid profiles. However, the effects of Mankai (R) alone on the composition and metabolic output of the human gut microbiota has not been fully investigated. Here, Mankai (R) was digested and fermented in vitro using a batch culture model of the proximal colon. Inulin and cellulose were used as readily and poorly fermentable control fibers respectively. Mankai (R) significantly stimulated the production of phenolic metabolites and short chain fatty acids by the gut microbiota (p<0.05). Three major microbial metabolites, 3-4-hydroxyphenyl propionic acid, 3-3-hydroxyphenyl propanoic acid and protocatechuic acid were significantly increased after 24 h fermentation. Moreover, Mankai (R) treatment lowered the overall microbial diversity (p<0.05), in line with a selective microbiome modulation.
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