4.7 Article

Betacyanins attenuates diabetic nephropathy in mice by inhibiting fibrosis and oxidative stress via the improvement of Nrf2 signaling

期刊

JOURNAL OF FUNCTIONAL FOODS
卷 81, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.jff.2021.104403

关键词

Diabetic nephropathy; Betacyanins (BCN); Fibrosis; Oxidative stress; Nrf2

资金

  1. Chongqing Research Program of Basic Research and Frontier Technology [cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjAX0784, cstc2018jcyjA1472, cstc2018jcyjAX0811, cstc2018jcyjA3533, KJZDM201801601]
  2. Schoollevel Research Program of Chongqing University of Education [KY201710B, 17GZKP01]
  3. Advanced Programs of Postdoctor of Chongqing [2017LY39]
  4. Science and Technology Research Program of Chongqing Education Commission of China [KJQN201901608, KJQN201901615, KJ1601402]
  5. Children's Research Institute of National Center for Schooling Development Programme
  6. Chongqing University of Education [CSDP19FSO1108]
  7. Chongqing Professional Talents Plan for Innovation and Entrepreneurship Demonstration Team [CQCY201903258]

向作者/读者索取更多资源

The study showed that plant-derived betacyanins (BCN) could alleviate diabetic nephropathy (DN) by reducing fibrosis and oxidative stress, mainly through improving the Nrf2 signaling pathway, subsequently improving renal function.
Diabetic nephropathy (DN) is a major cause of mortality in patients with diabetes, but there is a lack of effective therapeutic drugs for the disease treatment. Betacyanins (BCN) derived from plants exhibits anti-oxidative, antitumor and anti-inflammatory activities. However, its effects on DN have not been reported. In this study, we found that BCN supplementation markedly alleviated metabolic disorder and renal dysfunction in db/db mice. Additionally, BCN treatment obviously mitigated podocyte damage in diabetic mice, as evidenced by the decreased glomerular basement membrane thickness and the foot process width. Pathological analysis demonstrated that renal fibrosis was significantly inhibited by BCN through suppressing transforming growth factor (TGF)-beta 1/SMADs signaling in diabetic mice. Furthermore, diabetes-induced oxidative stress in kidney samples was evidently reduced in mice supplemented with BCN by improving nuclear factor erythroid-derived 2-related factor 2 (Nrf2) nuclear expression. The anti-fibrotic and anti-oxidant activities of BCN were confirmed in high glucose (HG)-stimulated podocytes in vitro. Importantly, we found that Nrf2 suppression could further exacerbate HG-induced collagen accumulation and reactive oxygen species (ROS) production in podocytes. Meanwhile, BCN-ameliorated fibrosis and oxidative stress were almost abrogated by the Nrf2 knockdown in HG-incubated podocytes. These findings elucidated that BCN could alleviate DN through reducing collagen and ROS deposition mainly through improving the Nrf2 signaling, subsequently alleviating renal dysfunction. Thus, BCN could be considered as a promising therapeutic agent for DN treatment.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据