期刊
ONCOTARGETS AND THERAPY
卷 14, 期 -, 页码 3803-3812出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S315998
关键词
cholesterol metabolism; immunotherapy; immune cell; therapeutic target; biomarker
资金
- National Natural Science Foundation of China [81802255]
- Young Talents in Shanghai [2019QNBJ]
- 'Dream Tutor' Outstanding Young Talents Program [fkyq1901]
- Clinical Research Project of Shanghai Pulmonary Hospital [fk18005]
- Key Discipline in 2019 (oncology), Project of Shanghai Municipal Science and Technology Commission (Project of Municipal Science and Technology Commission), Scientific research project of Shanghai Pulmonary Hospital [fkcx1903]
- Shanghai Municipal Commission of Health and Family Planning [2017YQ050]
- Innovation Training Project of SITP of Tongji University
- Youth project of hospital management research fund of Shanghai Hospital Association [Q1902037]
- grant of young talents in Shanghai
- key projects of leading talent [19411950300]
Cholesterol metabolism has been linked to tumor development and could offer a new breakthrough in immunotherapy. This study highlights how cholesterol metabolism impacts immune cell function within tumors and suggests that cholesterol levels could serve as a biomarker for predicting the efficacy of immunotherapy.
Checkpoint-based immunotherapies, such as programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors, have shown promising clinical outcomes in many types of cancers. Unfortunately, the response rate of immune checkpoint inhibitors is low. It is very important to discover novel therapeutic targets and prognostic biomarkers. Cholesterol metabolism has been demonstrated to be related to the occurrence and development of a variety of tumors and may provide a new breakthrough in the development of immunotherapy. First of all, cholesterol metabolism in the tumor microenvironment affects the function of tumor-infiltrating immune cells. In addition, intracellular cholesterol homeostasis is an important regulator of immune cell function. Furthermore, drugs that act on cholesterol metabolism affect the efficacy of immunotherapy. What is more, peripheral blood cholesterol level can be a biomarker to predict the efficacy of immunotherapy. In this review, we aimed to explore the potential role of cholesterol metabolism on immunotherapy. By summarizing the major findings of recent preclinical and clinical studies on cholesterol metabolism in immunotherapy, we suggested that cholesterol metabolism could be a potential therapeutic target and a prognostic biomarker for immunotherapy.
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